COURSE OF THE CORASOLUM-INDUCED SEIZURES IN RATS AT VARIOUS PERIODS AFTER EXPOSURE TO IONIZING RADIATION (in Russian)
It was attempted to clarify the behavior of the-brain of the rat during the early period after irradation. An excitation method involving pharmacologically induced seizures was used for the tests; seizures represent an excellent tool for studying the interaction between defense mechanisms and injury factors because they interfere with the equilibrium. Male white rats were exposed to whole-body x radiation of 750 r, carrying out the tests 1, 2, 4, 6, 9, 12, group contained animals injected with 60 or 100 mg/kg of corasolum, and control specimens that were injected but not irradiated. It was found that during the first 4 hours after exposure, the seizure reaction following the injection of corasolum was accelerated, resulting in higher intensity and increased mortality. The difference between irradiated and unirradiated animals tended to decrease during the 6 a 8 hours after exposure but after 24 hours an accelerated reaction was noted again. During the period ranging from 36 to 72 hours, a greater difference in the reaction was noted between the two doses: the 60 mg/kg body weight dose resulted in a decrease of the differential behavior of irradiated and unirradiated specimens while the 100 mg/kg dose caused a general weakening of the reaction. (TTT)
- Research Organization:
- Pavlov Inst. of Physiology, Leningrad
- NSA Number:
- NSA-17-030340
- OSTI ID:
- 4695417
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Vol. Vol: 3; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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