CONCENTRATION OF DESOXYRIBOPOLYNUCLEOTIDES IN RADIOSENSITIVE AND RADIORESISTANT TISSUES AFTER IRRADIATION

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Compt. Rend. Soc. Biol.

OSTI ID:4694926

Matyasova, J; Skalka, M; Soska, J

A study was made to determine the relation between the radiosensitivity of a tissue (or the rapidity of its nucleic metabolism) and the liberation of desoxyribopolynucleotides after irradiation. Mice of the H race and Wistar rats were used in the study. They were decapitated four hours after whole-body irradiation with a dose of 600 r. The concentration of the desoxyribopolynucleotides was determined in the spleen, thymus, liver, and kidneys. The results are shown graphically. In order to determine the participation of lymphocytes in the release of desoxyribopolynucleotides, tests were made on mice that received injections of cortisone for seven days before irradiation. The increase in desoxyribopolynucleotides after irradiation in the spleen is much less than in normal mice, whereas in the thymus the increase is insignificant. The increase of the concentration of desoxyribopolynucleotides after irradiation does not occur in all radiosensitive tissues with rapid exchange of DNA. This change occurs only in lymphatic and hematopoietic tissues. (J.S.R.)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-17-028727
• OSTI ID: 4694926
• Journal Information: Compt. Rend. Soc. Biol., Journal Name: Compt. Rend. Soc. Biol. Vol. Vol: 157
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ADRENAL GLANDS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BODY
CORTISONE
DIAGRAMS
DNA
HORMONES
IRRADIATION
KIDNEYS
LIVER
LYMPHOCYTES
METABOLISM
MICE
NUCLEIC ACIDS
NUCLEOTIDES
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIOSENSITIVITY
RATS
SPLEEN
STEROIDS
THYMUS
TISSUES