CONTINUOUS IRRADIATION OF THE RAT AT HIGH DOSE RATES: A STUDY OF JEJUNAL DAMAGE, RECOVERY, AND RADIORESISTANCE USING TRITIATED THYMIDINE
thelium of the rat to continuous irradiation at 415 rads/day. A steady or near-steady state was shown to develop with crypt cells taking up increased quantities of thymidine. The jejunal epithelium appeared to become more radioresistant to an acute dose of irradiation. When rats were removed from continuous irradiation, the villi soon returned to normal length, whereas the crypt mitotic counts increased considerably within 1 day. The crypt cells continued to take up increased quantities of thymidine. Intravenous isologous marrow, if given to continuously irradiated rats, will reduce the likelihood of a hemorrhagic type of death if administered after not more than 5 days total irradiation at the above dose rate. (P.C.H.)
- Research Organization:
- Royal Cancer Hospital, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-023152
- OSTI ID:
- 4692154
- Journal Information:
- Radiation Res., Journal Name: Radiation Res. Vol. Vol: 18
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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