CONSIDERATIONS ON THE CHANGES IN THE BLOOD CAPILLARIES AFTER IONIZING RADIATIONS. II. HISTOLOGIC AND HISTOCHEMICAL STUDY OF THE BLOOD CAPILLARIES OF THE FROG TONGUE AFTER SINGLE EXPOSURE TO X RAYS 2000,5000,10,000 r

Journal Article · Tue Nov 01 00:00:00 EST 1960 · Rivista di Anatomia Patologica e di Oncologia (Italy)

OSTI ID:4692115

Marin, A; Meneghini, C; Mezzanotte, S; Scarpis, U

The tongue was examined microscopically with various staining techniques 5, 15, and 30 days postirradiation. The mucous glands were consistently reduced in thickness, independent of the dose. As seen by the periodic acid-Schiff (PAS) reaction, the polysaccharide material took on a homogeneous appearance after irradiation in contrast to its granular form in control sections. The number of capillary vessels appeared to be increased 5 days after irradiation at all dose levels, whereas after 15 days the number was fewer than in control specimens. At 30 days, further changes were noted: with the 2000-r dose the number of vessels was normal but with the 2 higher doses the number was below normal and many vessels were occluded. The occlusion resulted from hypertrophy of endothelial cells, and the basement membrane was thickened and stained more intensely than normal. The early apparent increase in the number of capillaries could not be traced to newly formed vessels but to dilatation of pre-existing ones. This increase in luminal diameter following irradiation was subsequently (at 15 to 30 days) obliterated by swelling of endothelium. Hemorrhagic changes were present at 5 days after all 3 doses but at 30 days were evident only after 5000 and 10 000 r. The findings are interpreted as indicating that interstitial polysaccharides are depolymerized by radiation and that the thickening of the capillary basement membrane represents increased permeability and accumulation of glycoproteins from the blood. (TCO)

• Research Organization: Universita, Padua
• NSA Number: NSA-17-023194
• OSTI ID: 4692115
• Journal Information: Rivista di Anatomia Patologica e di Oncologia (Italy), Vol. Vol: 18; Other Information: Orig. Receipt Date: 31-DEC-63
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
AMINES
ANIMALS
BIOCHEMISTRY
BLOOD
BLOOD VESSELS
CAPILLARIES
CARBOHYDRATES
CHEMICAL REACTIONS
CYTOLOGY
DIFFUSION
FROGS
GLANDS
GLYCOPROTEINS
HEMORRHAGE
IONIZATION
PAS
POLYMERIZATION
POLYSACCHARIDES
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
SALICYLIC ACID
SUGARS
THICKNESS
TISSUES
TONGUE
X RADIATION