Effect of Cell-Free Spleen Extract on Bone Marrow Megakaryocytes of Irradiated Guinea-Pigs

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Acta Haematologica

DOI:https://doi.org/10.1159/000207268· OSTI ID:4690015

Johnston, Jr., Joseph B.; Strike, Thomas A.

Megakaryocytic recovery was studied on the 9th postirradiation day in spleen-extract-treated guinea-pigs and in saline controls following 650 r (LD_5/20) whole-body Co⁶⁰ gamma radiation. An accelerated regeneration of these cells was found in the extract-treated group. Centers of active megakaryocytic regeneration were observed in the marrow of animals in both groups. The incidence of these centers correlated well with survival in the two groups. Accelerated megakaryocytic regeneration appears to be one of the mechanisms by which cell-free spleen extract may reduce radiation mortality.

• Research Organization: National Naval Medical Center, Bethesda, Md.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-027073
• OSTI ID: 4690015
• Journal Information: Acta Haematologica, Journal Name: Acta Haematologica Journal Issue: 3 Vol. 28; ISSN 0001-5792
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BODY
BONE MARROW
COBALT 60
GAMMA RADIATION
MEGAKARYOCYTES
RADIATION DOSES
RADIATION PROTECTION
REGENERATION
SPLEEN