Notes on the Problems of the Transplantation of Kidneys in Dogs
In a group of 29 mongrel dogs kidney homotransplantation was performed. In five dogs an autograft was performed to check the suitability of the surgical technique. In the remaining 24 dogs kidney homografts were carried out, Five dogs served as controls; in these animals the functioning of the homografted kidney stopped after 8 days on the average, In 12 animals an attempt at the induction of immunological tolerance by exsanguinotransfusion, whole-body irradiation and 6-MP-administration was made. Induction of immunological tolerance by total exsanguinotransfusion immediately after birth may render possible a successful homograft even in adult life. The transplanted organ then exhibits a permanent take and takes over the function of the recipient's removed kidneys. One dog is alive with its single kidney homograft after almost two years. 6-MP administration may lead to such a degree of induced tolerance that the function of a kidney homograft is prolonged by a factor of two to three. Whole-body irradiation within a range of 400 rad (Co60 source) does not significantly prolong homograft survival.
- Research Organization:
- Safarik Univ., Kosice, Czechoslovakia
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-030379
- OSTI ID:
- 4686693
- Journal Information:
- Transplantation (Baltimore), Vol. 1, Issue 3; Other Information: Orig. Receipt Date: 31-DEC-63; ISSN 0041-1337
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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