The Radiation-Sensitizing Effects of N-Ethylmaleimide and Iodoacetic Acid on a Radiation-Resistant Micrococcus
The sulfhydryl group combining agents, N-ethylmaleimide (NEM) and iodoacetic acid (IAA), were investigated for their abilities to enhance gamma - radiation inactivation of Micrococcus radiodurans. At the nontoxic level of 100 mu M, the inactivation by irradiation was accelerated with IAA, but no effect was observed with NEM. The removal of O did not produce any detectable changes in the action of either chemical. The accelerated radiolethal effect appears to be due to the highly reactive radiolytic products of IAA and their nonspecific reactions with various cellular constituents.
- Research Organization:
- Oregon State Univ., Corvallis
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-033732
- OSTI ID:
- 4683641
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 4 Vol. 19; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETIC ACID
BACTERIA
CHEMICALS
ETHYL RADICALS
GAMMA RADIATION
IMIDES
MALEIC ACID
MICROCOCCUS RADIODURANS
NITROGEN COMPOUNDS
ORGANIC ACIDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION PROTECTION
RADIOCHEMISTRY
RADIOSENSITIVITY
ACETIC ACID
BACTERIA
CHEMICALS
ETHYL RADICALS
GAMMA RADIATION
IMIDES
MALEIC ACID
MICROCOCCUS RADIODURANS
NITROGEN COMPOUNDS
ORGANIC ACIDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION PROTECTION
RADIOCHEMISTRY
RADIOSENSITIVITY