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U.S. Department of Energy
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NEUTRON ACTIVATION CHROMATOGRAPHY

Thesis/Dissertation ·
OSTI ID:4677543
Methods were developed for the application of neutron activation analysis to the detection and quantification of biological compounds separated on paper chromatograms. Neutron activation chromatography was shown to be a practical method for the determination of molecules containing phosphorus and sulfur. The technique was extended to other biological compounds that are normally insensitive to activation analysis by chromatographing and activating bromine-containing derivatives of these materials. In addition, other related problems were studied, such as the sensitivity and precision of the method, the identification of contaminating elements in filter paper that produce undesirable background activity, the chemistry of the energetic bromine atoms produced by radiative capture of thermal neutrons, and the advantages of various counting methods. The method consists of neutron irradiation of compounds separated on paper chromatograms, then determination of the induced radioactivity in each compound by an appropriate counting technique. Compounds may be located by radioautography and identified by the usual chromatographic procedures. (Dissertation Abstr.)
Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-17-025159
OSTI ID:
4677543
Country of Publication:
Country unknown/Code not available
Language:
English