Radioprotection by Pressor Amidines
BS>Studies were made on the effects of pressor amidines and pharmacologically related amines on the radiosensitivity of mice exposed to about 100 r/min. The results showed that S-ethylisothiuronium is radioprotective when used over a wide dose range and for a considerable period of time. Also, papaverine, a known pharmacological antagonist significantly reduced the protective effect of a massive dose of S-ethylisothiuronium. It is suggested that pressor amidines offer radioprotective activity through a pharmacological mechanism, which leads to a lowered oxygen tension of radiosensitive tissues.
- Research Organization:
- Walter Reed Army Inst. of Research, Washington, D.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-031948
- OSTI ID:
- 4673559
- Journal Information:
- Science, Journal Name: Science Journal Issue: 3576 Vol. 141; ISSN 0036-8075
- Publisher:
- AAAS
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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