P$sup 32$ TREATMENT OF POLYCYTHEMIA VERA

Journal Article · Fri May 10 04:00:00 EDT 1963 · Aerztliche Forschung (West Germany) Discontinued

OSTI ID:4673446

Kellermann, T; Pabst, H W

Phosphorus-52 treatment of 30 patients over a 12-yr period is related and discussed with respect to dosage, clinical and histologic effects, and complications. The initial dose used was 0.1 mc P/sup 32/ per kg body wt. This usually resulted in a remission of erythrocyte count for 16 months. No close correlation was noted between the duration of remission and dose, nor did radioresistance develop after repeated P/sup 32/ doses. Remissions after three to four treatments generally exceeded the first in length. Maximum depression of red cell count was reached 4.5 months after treatment, and the mean post- treatment count was 4.05 x 10/sup 6/. Both leukocyte and platelet counts fell to below 50% of initial values; however, no serious side-effects were generally observed. Bone marrow biopsies, which initially showed hyperplasia of erythroid elements, indicated that P/sup 32/ probably does not directly inhibit cellular proliferation but, rather, acts on marrow blood vessels, and eventually causes fibrosis of marrow space. (TCO)

• Research Organization: Universitat, Munich
• NSA Number: NSA-17-033491
• OSTI ID: 4673446
• Journal Information: Aerztliche Forschung (West Germany) Discontinued, Journal Name: Aerztliche Forschung (West Germany) Discontinued Vol. Vol: 17; ISSN ARZFA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BLOOD VESSELS
BONE MARROW
DISEASES
EFFICIENCY
ERYTHROCYTES
LEUCOCYTES
MAN
PHOSPHORUS 32
POLYCYTHEMIA
QUANTITY RATIO
RADIATION DOSES
RADIOSENSITIVITY
RADIOTHERAPY