Strontium and its relation to calcium metabolism
Studies are reported in which Ca45 and Sr85 were injected intravenously into the same individual before and after treatments thought to affect Ca metabolism, and a method is proposed for expressing results that is independent of the scheme of either Ca or Sr metabolism, but that allows a quantitative comparison of the metabolic behavior of these nuclides. To avoid making any assumption concerning a Sr pool in the presentation of the data, each of the body processes (over-all loss, urinary excretion, fecal excretion, and bone uptake) is expressed in terms of its characteristic rate constant. A comparison of the Sr and Ca rate constants of the various process in 15 studies done on eight patients whose Ca metabolism differed widely revealed that these elements were not equivalent in any of these processes. Thus, in neither over- all loss, urinary excretion, fecal excretion, nor bone uptake was it possible to establish a ratio of the corresponding rate constants that varied only within the limits of error of the mean ratio. It was not possible to establish a significant correlation (by means of regression functions) between the corresponding rate constants calculated for each element. Whereas the mean values of the total and urinary rate constants of Sr differed significantly from the corresponding Ca constants, the fecal and bone rate constants of the two elements did not so differ. Values for individual patients of these latter two rate constants appear as if distributed by change within the experimental range, with the result that the mean ratios of the rate constants of the two elements approach unity. It is concluded that, qualitatively, both Sr and Ca follow the same metabolic pathways, and quantitatively, the use of Sr as a tracer for Ca in a given individual leads only to an approximation of the true value, the degree of error varying unpredictably for a particular case.
- Research Organization:
- Hospital for Special Surgery, New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-035426
- OSTI ID:
- 4670404
- Journal Information:
- Journal of Clinical Investigation, Journal Name: Journal of Clinical Investigation Journal Issue: 7 Vol. 42; ISSN 0021-9738
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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