RADIATION-INDUCED CARBOXYLATION REACTIONS OF ALIPHATIC AMINO ACIDS AND MONOCARBOXYLIC ACIDS

Journal Article · Mon Jul 01 00:00:00 EDT 1963 · Radiation Res.

DOI:https://doi.org/10.2307/3571474· OSTI ID:4669067

Liebster, J; Kopoldova, J; Babicky, A

The carboxylation reactions occurring in irradiated aqueous solutions of aliphatic amino acids were investigated for aminobutyric acid, norvaline, valine, norleucine, leucine, and isoleucine. The products of the fixation of C/sup 14/O/ sub 2/ in these amino acids were identified. The effects of the radiation dose, the concentration and the ratio of amino acid to C/sup 14/O/sub 2/ on the yields of glutamic acid from alpha aminobutyric acid as well as the optimum conditions for this reaction were determined. An exchange reaction between the carboxyl group of the amino acid and C/sup 14/O/sub 2/ was observed. A similar study was made for the aliphatic monocarboxylic acids from C-2 to C-8, and the yields of the dicarboxylic acids formed were compared. An increased fixation of CO/sub 2/ was observed with growing chain length. The optimum conditions for the carboxylation of valeric acid were investigated. (auth)

• Research Organization: Inst. for Biological Research, Czechoslovak Academy of Sciences, Prague
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-034033
• OSTI ID: 4669067
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 19
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKYL RADICALS
AMINES
AMINO ACIDS
AMINOBUTYRIC ACID
BUTYL RADICALS
BUTYRIC ACID
CARBON 14
CARBON DIOXIDE
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHEMISTRY
CONFIGURATION
DIAGRAMS
EFFICIENCY
ETHYL RADICALS
GLUTAMIC ACID
HEXANE
IRRADIATION
ISOLEUCINE
ISOMERS
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
MEASURED VALUES
MOLECULES
ORGANIC ACIDS
ORGANIC NITROGEN COMPOUNDS
PENTANE
PROPYL RADICALS
QUANTITY RATIO
RADIATION CHEMISTRY
RADIATION DOSES
SOLUTIONS
VALERIC ACID
VALINE
WATER