Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter
- Univ. of Iowa, Iowa City, IA (United States); and others
This report describes the localization of the human LCP2 gene to human chromosome 5q33.1-qter using single-stranded conformation polymorphisms analysis. This gene encodes an SH2 domain containing leukocyte protein of 76 kDa (SLP-76), which plays a functional role in T-cell activation. It remains to be determined whether mutations in this gene or translocations at this chromosome location are the genetic basis for various diseases, including lymphoblastic leukemia. 12 refs., 1 fig.
- OSTI ID:
- 466050
- Journal Information:
- Genomics, Vol. 35, Issue 1; Other Information: PBD: 1 Jul 1996
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
DNA-CLONING
GENE REGULATION
GENETIC MAPPING
GENE MUTATIONS
SPLICING
DNA SEQUENCING
HUMAN CHROMOSOME 5
CHROMOSOMAL ABERRATIONS
MAN
HEREDITARY DISEASES
LEUKEMIA
HUMAN CHROMOSOME 14
PHOSPHOTRANSFERASES
TYROSINE
POLYMERASE CHAIN REACTION
ELECTROPHORESIS
STATISTICS
BIOLOGICAL MARKERS
BASIC STUDIES
GENES
DNA-CLONING
GENE REGULATION
GENETIC MAPPING
GENE MUTATIONS
SPLICING
DNA SEQUENCING
HUMAN CHROMOSOME 5
CHROMOSOMAL ABERRATIONS
MAN
HEREDITARY DISEASES
LEUKEMIA
HUMAN CHROMOSOME 14
PHOSPHOTRANSFERASES
TYROSINE
POLYMERASE CHAIN REACTION
ELECTROPHORESIS
STATISTICS
BIOLOGICAL MARKERS