Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0320· OSTI ID:466016

Pecker, I; Savitsky, K; Rotman, G ^[1]

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1. Tel Aviv Univ., Ramat Aviv (Israel); and others

Atm, the mouse homolog of the human ATM gene defective in ataxia-telangiectasia (A-T), has been identified. The entire coding sequence of the Atm transcript was cloned and found to contain an open reading frame encoding a protein of 3066 amino acids with 84% overall identity and 91% similarity to the human ATM protein. Variable levels of expression of Atm were observed in different tissues. Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23. 32 refs., 6 figs.

• OSTI ID: 466016
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 35; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
CHROMOSOMES
DNA SEQUENCING
DNA-CLONING
FLUORESCENCE
GENE REGULATION
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOMES
IN-SITU HYBRIDIZATION
MAN
MICE
POLYMERASE CHAIN REACTION
PROTEINS
RADIOSENSITIVITY
RECESSIVE MUTATIONS
STATISTICS
TELANGIECTASIS
TISSUE DISTRIBUTION