Effect of Pretreatment with Colchicine or a Colchicine Derivative on Hemopoiesis in Irradiated Mice
Treatment of mice with colchicine or trimethylcolchicine acid methyl ether prior to irradiation caused an increase in bone marrow cellularity which was apparent 3 days after LD5 irradiation; no significant increase in granulocyte counts 3 to 4 days after irradiation; a relatively small but significant increase in lymphocyte counts 3 to 4 days after irradintion; an advance in the time of recovery of granulocyte counts consistent with the effect on survival, which was equivalent to a mean dose-reduction of 180 rads; and a similar advance in the time of recovery of lymphocyte counts.
- Research Organization:
- National Cancer Inst., Bethesda, Md.; National Heart Inst., Bethesda, Md.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-033734
- OSTI ID:
- 4659647
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 4 Vol. 19; ISSN 0033-7587
- Publisher:
- Radiation Research Society
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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