Protection by superoxide dismutase of white blood cells in x-irradiated mice

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(78)90611-2· OSTI ID:5774546

Petkau, A; Chelack, W S; Pleskach, S D

In x-irradiated mice the loss of white blood cells increases exponentially with dose. The dose x/sub 0/, which reduces the cell number to 1/e, is 115 +- 15, 205 +- 30, 108 +- 5, and 235 +- 18 rad for leucocytes, granulocytes, lymphocytes and platelets, respectively. The x/sub 0/ value increases with the amount of endogenous superoxide dismutase per cell. Intravenous bovine superoxide dismutase has no effect on the x/sub 0/ for granulocytes and platelets but increases it to 145 +- 15 and 143 +- 20 rad for leucocytes and lymphocytes, respectively. The exogenous enzyme also shortens the delay in recovery of the white blood cells, particularly after x-ray doses of 550 and 675 rad. The earlier hematological recovery is attributable to the known radioprotective effect of the enzyme on bone marrow stem cells.

• Research Organization: Atomic Energy of Canada Ltd., Pinawa, Manitoba
• OSTI ID: 5774546
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 22:10; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
HEMATOLOGY
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MEDICINE
MICE
RADIATIONS
RADICALS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
SUPEROXIDE RADICALS
VERTEBRATES
X RADIATION