Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1
- Australian National Univ., Canberra (Australia); and others
In this study, we have isolated and characterized a gene and cDNA encoding a mouse Theta class GST. The gene, mGSTT2, spans approximately 3.1 kb and is composed of five exons interrupted by four introns. The gene was localized to Chromosome 10B5-C1 by in situ hybridization. Southern blot analysis of mouse genomic DNA suggests that there is only one copy of mGSTT2 in the mouse genome. The cDNA derived from mGSTT2 was isolated from a mouse liver cDNA library and has an open reading frame of 732 bp encoding a peptide of 244 amino acids with a calculated molecular weight of 26,676 Da. The encoded protein shares amino acid sequence identities of 92, 77, 51 and 55% with rat subunit Yrs, human subunit GSTT2, rat subunit 5, and human subunit GSTT1, respectively. 39 refs., 6 figs.
- OSTI ID:
- 465930
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 33; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AMINO ACID SEQUENCE
CARCINOGENS
CHROMOSOMES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
GENE REGULATION
GENETIC MAPPING
GLUTATHIONE CONJUGATES
HUMAN CHROMOSOME 22
IN-SITU HYBRIDIZATION
MAMMALS
METABOLISM
MICE
MUTAGENS
NUCLEOTIDES
STRUCTURE-ACTIVITY RELATIONSHIPS
TISSUE DISTRIBUTION
TRANSFERASES
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AMINO ACID SEQUENCE
CARCINOGENS
CHROMOSOMES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
GENE REGULATION
GENETIC MAPPING
GLUTATHIONE CONJUGATES
HUMAN CHROMOSOME 22
IN-SITU HYBRIDIZATION
MAMMALS
METABOLISM
MICE
MUTAGENS
NUCLEOTIDES
STRUCTURE-ACTIVITY RELATIONSHIPS
TISSUE DISTRIBUTION
TRANSFERASES