Radiosensitive Molecular Weight of Single-Stranded Virus Nucleic Acids
- Pennsylvania State Univ., University Park, PA (United States)
Samples of X174 virus, X174-DNA, R17 virus, and R17RNA in tryptone broth were exposed to x and gamma radiation under carefully controlled conditions. Inactivation data were used to determine the molecular weights and target sizes of the viruses. The effects of reduced glutathione, oxidized glutathione, sodium phosphate buffer, and pH on results were measured. Results are compared with results from previous studies on the tobacco mosaic virus (TMV) and TMV-RNA. It is concluded that valid radiatron target molecular weights for small viruses and their free nucleic acids can be obtained by taking due cognizance of radiation modifying effects of added agents.
- Research Organization:
- Pennsylvania State Univ., University Park, PA (United States)
- Sponsoring Organization:
- US Atomic Energy Commission (AEC)
- NSA Number:
- NSA-17-033714
- OSTI ID:
- 4653892
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 199
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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