HEPATIC DAMAGE BY RETICULOENDOTHELIAL INTERFERENCE

Journal Article · Fri Feb 01 04:00:00 EST 1963 · Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med.

OSTI ID:4647193

Fisher, E R; Fisher, B

During an investigation of the effect of reticuloendothelial system (RES) interference on the incidence and growth of induced hepatic metastases of Walker 256 carcinoma in Sprague-Dawley rats, it was observed that blocking doses of India ink and Thorotrast (stabilized ThO/sub 2/) produced an increase of hepatic metastases associated with elevations of serum glutamic-oxalacetic (SGOT) and glutamic-pyruvic (SGPT) transaminases. It is thus suggested that the effect of these agents on the incidence of hepatic metastases might not necessarily be related to inhibition of a particular RES function but to liver damage. To test this possibility, blockade of the RES with Proferrin (saccharated iron oxide) in rats and Proferrin, carbon, and Thorotrast in rabbits was carried out. Such blockade caused elevation of SG0T and SGPT, but stimulation of RES in rats with endotoxin resulted in elevation of SG0T and decrease in SGPT and was without effect on these enzymes in rabbits. Proferrin in stimulating doses produced elevation of SGOT in rats and rabbits and a decrease in SGPT in rabbits. RES stimulation with BCG produced elevation of SGOT and SGPT in rats but only SGOT in rabbits. Although overt hepatic necrosis was not evident in histologic sections of livers from animals exhibiting changes in SGOT and SGPT, an increase in mitoses of parenchymal cells was apparent. Lung, myocardium, adrenals, and skeletal muscle did not reveal morphologic change. Changes in SG0T and S0PT seem to reflect hepatic parenchymal cell damage, and it is unlikely that the damage is related to altered hepatic blood flow resulting from sinusoidal compression, although the latter was conspicuous following the use of colloidal agents in either blocking or stimulating doses. (BBB)

• Research Organization: Univ. of Pittsburgh
• NSA Number: NSA-17-035417
• OSTI ID: 4647193
• Journal Information: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med., Journal Name: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med. Vol. Vol: 75; ISSN ARPAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
BACTERIA
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BONES
CARBON
CARCINOGENESIS
COLLOIDS
DRUGS
DYES
ENZYMES
HEART
INDIA INK
IRON OXIDES
LIVER
LUNGS
LYMPH SYSTEM
METASTASES
MITOSIS
MUSCLES
RABBITS
RATS
SUGARS
THORIUM OXIDES
THOROTRAST
TRANSAMINASES