DEPENDENCE OF FREQUENCY OF X-RAY-INDUCED CHROMOSOME ABERRATIONS ON DOSE RATE IN THE CHINESE HAMSTER

Journal Article · Thu Aug 15 04:00:00 EDT 1963 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.50.2.322· OSTI ID:4640177

Brewen, J. G.

The observed frequency of chromatid aberrations was different at each of three dose rates used in the irradiation of the corneal epithelium of the Chinese hamster. The difference was manifested in the frequency of chromatid deletions as well as chromatid exchanges. When the corneal epithelium was treated with puromycin at the three dose rates, the same frequency of aberrations was observed at all three dose rates. The frequency was the same as that observed at the highest dose rate without treatment with puromycin. Puromycin inhibits protein synthesis, which is known to be necessary for the rejoining of chromosomal breaks. Therefore, it appears that the effect of dose rate is a differential effect on the rejoining system. (P.C.H.)

• Research Organization: Johns Hopkins Univ., Baltimore
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-035548
• OSTI ID: 4640177
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Issue: 2 Vol. 50; ISSN 0027-8424
• Publisher: National Academy of Sciences, Washington, DC (United States)
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMALS
ANTIBIOTICS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CHROMOSOMES
EYES
HAMSTERS
MALFORMATIONS
PROTEINS
PUROMYCIN
RADIATION DOSES
RADIATION INJURIES
X RADIATION