INEFFECTIVENESS OF LIPOTROPIC SUBSTANCES IN POSTIRRADIATION FATTY INFILTRATION OF THE LIVER

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Folia Biologica (Prague) (Czechoslovakia)

OSTI ID:4635588

Skalka, M

The possibility of a disturbance by irradiation of the metabolism of lipotropic substances, especially chloine and methionine, which results in fatty infiltration of the liver was investigated. Adult strain H mice were fed on a standard Larsen diet with water ad lib. Choline hydrochloride was administered intraperitoneally in amounts of 1 mg in 0.1 ml saline per mouse daily starting on the sixth day. L-methionine was administered by the same route in amounts of 5 mg/10 g on the third, fifth, seventh, ninth, and eleventh days postirradiation. The Soviet Preparation Lipokain was used as the lipocaic pancreatic factor. The animals were given 820 and 630 r doses of x radiation. It was found that administration of the lipotropic substances choline, methionine, and lipocaic did not influence fatty infiltration of the liver that occurs in mice subjected to whole-body irradiation with a large dose of x rays during the bone marrow syndrome. (H.M.G.)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-17-040586
• OSTI ID: 4635588
• Journal Information: Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 9; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
CHOLINE
DIET
DIFFUSION
EFFICIENCY
ENZYMES
ESTERS
HORMONES
INTESTINE
IRRADIATION
LETHAL DOSE
LIPIDS
LIVER
METABOLISM
METHIONINE
MICE
ORGANIC ACIDS
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION SICKNESS
VITAMIN B GROUP
VITAMINS
WATER
X RADIATION