INTERSTITIAL RADIOISOTOPE IRRADIATION OF BRAIN TUMORS WITH COMPARATIVE LONG- TERM RESULTS OF DEEP X-RAY THERAPY

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Acta Neurochirurgica (Austria)

DOI:https://doi.org/10.1007/BF01414199· OSTI ID:4634904

Mundinger, F

Radioisotope (Co/sup 60/, Ta/sup 182/, Ir/sup 192/, Au/sup 198/) implantation techniques for interstitial radiation are described, and comparative statistical evaluation is made for the mean survival time of 157 patients with primary tumors of the cerebral hemispheres. This series was treated with combined operative and interstitial radioisotope implantation therapy or with combined operative and deep radiation therapy. The percentage overall survival rate was 80% higher after postoperative interstitial radioisotope treatment. Among individual groups, in cases with glioblastoma with postoperative Co/sup 60/ treatment there was a significant prolongation of mean survival time of approximates 29%, and with tumors in the frontal region there was a prolongation, depending on the dosage, of approximates 87% (16.8 months) or 106% (21.3 months). The 18% of patients still surviving show a mean survival time of 41.7 months. With astrocytoma there was no significant difference in the two groups. The treated patients who died of ependymona lived a significant 1.5 times longer (21.4 months), while the 50% of patients who survived to the present had a 54% improved mean survival time of 3.7 yr. The treated patients who died of oligodendroglioma showed a significant increase of mean survival time of 30% (21.8 months), while the 71% of patients still surviving showed an increased mean survival time of 45% (64.9 months). Of the methods of interstitial irradiation investigated, Co/sup 60/ postoperative treatment showed the best results. Undifferentiated or angioblastic meningiomata, which could not be completely removed at operation because of their site or because of technical difficulties (e.g., hemorrhage), were coated during operation with Ir/sup 192/. As a result of obliteration of the vessels and shrinkage of the remaining portion of the tumor, their subsequent total removal was made considerably easier. One advantage of interstitial radiation is the reduction of 3/4 to 2/3 in the time of treatment in comparison with deep radiation therapy. Dosimetry data are provided showing the distribution of dosage in brain tissues surrounding pellets of Co/sup 60/ of various size, shape, and radioactivity. Protective devices for shielding other patients and medical personnel from hospitalized patients bearing these radioisotopes are described and illustrated. (BBB)

• Research Organization: Neurochirurgische Universitatsklinik, Freiburg i.B.
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-038648
• OSTI ID: 4634904
• Journal Information: Acta Neurochirurgica (Austria), Journal Name: Acta Neurochirurgica (Austria) Vol. Vol: 11; ISSN ACNUA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ASTROCYTOMAS
BIOLOGY AND MEDICINE
BLOOD VESSELS
BRAIN
COBALT 60
DISTRIBUTION
EFFICIENCY
GLIOBLASTOMAS
GOLD 198
IRIDIUM 192
MAN
MEASURED VALUES
NERVOUS SYSTEM
PELLETS
PERSONNEL
RADIATION DOSES
RADIATION PROTECTION
RADIOTHERAPY
SHIELDING
STATISTICS
SURGERY
SURVIVAL TIME
TANTALUM 182
TUMORS
X RADIATION