Pleurectomy and intraoperative brachytherapy and postroperative radiation in the treatment of malignant pleural mesothelioma

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90050-6· OSTI ID:6905017

Hilaris, B S; Nori, D; Kwong, E; Kutcher, G J; Martini, N

Forty-one patients with diffuse, pleural mesothelioma limited to one hemi-thorax underwent a thoracotomy at Memorial Sloan-Kettering Cancer Center from January 1976 to July 1982. Treatment at thoracotomy consisted of as complete a parietal pleurectomy as was possible to remove the bulk of the tumor. Measurable gross residual disease was treated whenever feasible, with permanent /sup 125/I implantation; residual diffuse disease was treated by a temporary /sup 192/Ir implantation or by postoperative instillation of /sup 32/P. External radiation therapy was given 4-6 weeks postoperatively to the involved hemi-thorax, shielding the lung and utilizing a combination of electron an a photon beam. A dose of 4500 rad in 4.5 weeks was given to the pleural surface by the mixed beam. There was no postoperative mortality in this group of 41 patients. Complications developed in 6 patients (15%). The median survival was 21 months; the one year survival was 65% and the two year survival was 40%. The median disease-free survival was 11 months and the one and two year disease-free survival 44 and 13% respectively. This study suggests that the combination of pleurectomy, intraoperative brachytherapy and postoperative external radiation increased the local control of the tumor and prolonged the survival.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 6905017
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON BEAMS
ELECTRON CAPTURE RADIOISOTOPES
ENERGY RANGE
ESOPHAGUS
FIBROSIS
HARD X RADIATION
HEAVY NUCLEI
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 125
IODINE ISOTOPES
IONIZING RADIATIONS
IRIDIUM 192
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTON BEAMS
LIGHT NUCLEI
LUNGS
MEDICINE
MEV RANGE
MEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTICLE BEAMS
PATHOLOGICAL CHANGES
PATIENTS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PNEUMONITIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
SYMPTOMS
THERAPY
X RADIATION
YEARS LIVING RADIOISOTOPES