ELECTRON MICROSCOPIC STUDY OF CHANGES IN LIVER CELLS AFTER COMBINED TREATMENT WITH CARBON TETRACHLORIDE AND X RAYS (in Italian)
Adult rats were treated with low doses of both CCl/sub 4/ and x rays, shown previously not to produce ultrastructural changes in liver parenchymal cells when given separately. The rats were exposed to a single, whole-body, 200- r dose of 160-kv x rays and then injected subcutaneously with 0.1 ml of a 30% solution of CCl/sub 4/ in peanut oil, corresponding to 0.15 ml CCl/sub 4/ per 100 g body wt. When the rats were sacrificed three days later, all showed pronounced changes in mitochondria and endoplasmic reticulum of liver cells, which were not seen following either individual treatment. The mitochondria showed marked swelling, detachment of cristae, and accumulation of granular material in their interior. Endoplasmic reticulum underwent dilatation and detachment of normally adherent ribonucleoprotein granules. A different picture was observed following injection of toxic doses of CCl/sub 4/ (0.5 m1/100 g body wt). This produced marked disruption and ballooning of mitochondria and endoplasmic reticulum. The results indicate that subliminal doses of CCl/sub 4/ and x rays, presumably acting by different mechanisms, synergistically damage the liver cell, particularly its mitochondria. (BBB)
- Research Organization:
- Universita, Milan
- NSA Number:
- NSA-17-038775
- OSTI ID:
- 4634683
- Journal Information:
- Atti Accad. Med. Lombarda, Vol. Vol: 17; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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