DEHYDRASE ACTIVITY OF TISSUES AFTER THE TREATMENT WITH LOW TEMPERATURE AND IONIZING RADIATIONS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4631130

Ledentsov, Yu K

White rats were used to study the activity of certain dehydrogenases in various tissues during local hypothermia and whole-body x irradiation. A condition of hypothermia was accomplished by application, to hind extremities of the animals, of a rubber bladder filled with a refrigerating mixture for 90 minutes. Within 24 hrs, the action of hypothermia resulted in 2nd to 3rd degree frostbite of the hind legs. Hypothermia of the skin followed. The animals were given a 700 r whole-body dose of x radiation. Activity of glutamicodehydrogenase, lacticodehydrogenase, and succinic dehydrogenase was determined in the liver, muscles, and brain of both groups. Those animals subjected to cold stress were decapitated immediately after hypothermia, whereas x-irradiated animals were investigated on the 7th day postirradiation. In a further experiment hypothermia was induced in x-irradiated animals. In the group subjected to local cold stress there was a marked increase of dehydrogenase activity of the liver, a noticeable increase in lacticodehydrogenase activity in the brain, and no detectable change in muscle dehydrogenases. Animals with pronounced manifestations of radiation sickness showed a significant decrease in glutamicodehydrogenase activity in the liver as well as a tendency toward decrease of succinic dehydrogenase activity in all investigated organs. In irradiated animals subjected to hypothermia, a noticeable decrease in dehydrogenase activity was observed. Data are discussed in terms of compensatory biochemical manifestations of the thermal regulatory mechanism. (H.M.G.)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-037097
• OSTI ID: 4631130
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AMINO ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BODY
BRAIN
DEHYDROGENASES
ENZYMES
GLUTAMIC ACID
LACTIC ACID
LIVER
MUSCLES
ORGANIC ACIDS
RADIATION DOSES
RADIATION SICKNESS
RATS
SKIN
SUCCINIC ACID
TEMPERATURE
TISSUES
VARIATIONS
X RADIATION