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EFFECT OF A RAISED OXYGEN CONCENTRATION IN AIR INHALED DURING IRRADIATION ON THE SURVIVAL OF IRRADIATED MICE AND THE PROTECTIVE EFFECT OF CYSTEINE

Journal Article · · Folia Biologica (Prague) (Czechoslovakia)
OSTI ID:4623329
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The effect of a raised oxygen concentration in inhaled air on mortality among mice irradiated with a dose of LD/sub 50/30 and LD/sub 50/30/ was studied. No difference was found in mortality among animals irradiated in air (21% O/sub 2/ ) or in a pure (100%) oxygen atmosphere. Mortality among animals irradiated in a mixture of 95% O/sub 2/ and 5% CO/sub 2/, however, was 92%. Oxygen tension in the brain, intestine, liver, spleen, and muscle rose during the inhalation of oxygen and remained high during the whole time of administration of O/sub 2/. It is assumed that the increase in mortality on inhalation of 95% O/sub 2/ + 5% CO/ sub 2/ is due to a change in the diffusion of oxygen into the cells. The intraperitoneal administration of cysteine in a dose of 900 mg/kg seven minutes before irradiation protected all animals irradiated with a dose of the animals were protected. The inhalation of pure oxygen after the injection of cysteine, either before or during irradiation, inhibited the protective effect of the cysteine. It is assumed that the decrease in the protective effect of cysteine is due to its oxidation by the raised amount of oxygen in the tissues. (auth)

Research Organization:
Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
NSA Number:
NSA-17-040583
OSTI ID:
4623329
Journal Information:
Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 9; ISSN FOBLA
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

AIR
ANIMAL CELLS
BIOLOGY AND MEDICINE
BRAIN
CARBON DIOXIDE
CYSTEINE
DRUGS
INTESTINE
IRRADIATION
LETHAL DOSE
LIVER
LUNGS
MEDICINE
METABOLISM
MICE
MUSCLES
OXIDATION
OXYGEN
QUALITATIVE ANALYSIS
QUANTITY RATIO
RADIATION INJURIES
RADIATION PROTECTION
RADIOSENSITIVITY
SPLEEN
SURVIVAL TIME
TISSUES
VARIATIONS