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ABSENCE OF SUMMATION OF PROTECTIVE EFFECT OF CYSTEINE AND ACTH IN IRRADIATION OF RATS BY X-RAY (in Russian)

Journal Article · · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
OSTI ID:4274995
;
ABS>The protective effect of various doses of cysteine and ACTA as well as the combined action of both preparations was studied. Experiments were carried out on rats, irradiated by x ray doses of 600 to 700 r. As a result of experimental work it was established that intruction of ACTH 1 unit per day for 3 to 7 days previous to irradiation decreases the death rate of irradiated animals. The most pronounced effect was obtained by introducing the hormone for 6 days. Large doses of ACTH or its prolonged administration decreased its positive effect. The introduction of protective dose of ACTH was ineffective when cystein was given before irradiation in doses which had a protective effect on animals not treated by ACTH beforehand. On the contrary, combined treatment of rats by ACTH and cystein accelerated the death of the animals. (auth)
Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-13-009624
OSTI ID:
4274995
Journal Information:
Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 4, No. 1; ISSN MERAA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

ACTH
BIOLOGY AND MEDICINE
CYSTEINE
HORMONES
RADIATION DOSES
RADIATION PROTECTION
RATS
SURVIVAL TIME
X RADIATION