Response of the skin of swine to increasing exposures of 250 kvp x-ray
Conference
·
OSTI ID:4617891
The gross and histological features of the skin of swine resemble those of the human being sufficiently to warrant its use as an in-vivo system for the evaluation and comparison of the effects of different ionizing radiations and the extrapolation of these results to humans. As the initial part of studies designed to compare the effects of X-rays and neutrons, detailed gross and cytological effects have been determined as a function of time following increasing doses of 250 kvp X-ray to 10 cm in diameter fields on the shoulder and lower back of 60- to 100-lb immature swine. The effects produced following single exposures over a range from 1760 to 2800 R have been evaluated on the basis of the number of moist reactions produced, that healed or failed to heal. Erythema and epilation time-dose changes were determined but not evaluated. The moist reaction begins about the 18th to 21st days and is maximumly developed at about 28 days following irradiation. Healing, if it occurs, is complete or at a maximum between 35 and 49 days. The highest exposure at which a moist reaction did not occur was 2700 R. However, complete ulceration also was seen occasionally following exposures as low as 1900 R; thus there is an overlap of 800 roentgens where healing or ulceration may occur. The exposure at which 50% of the irradiated fields are healed at the end of the observation period of 49 days is estimated to be 2350 R. These results furnish a standard with which the effectiveness of other radiations is being compared. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, NY (United States)
- Sponsoring Organization:
- US Atomic Energy Commission (AEC)
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-20-001609
- OSTI ID:
- 4617891
- Report Number(s):
- BNL--9477
- Country of Publication:
- United States
- Language:
- English
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