Soluble transition metals mediate residual oil fly ash induced acute lung injury

Journal Article · Fri Feb 21 04:00:00 EST 1997 · Journal of Toxicology and Environmental Health

OSTI ID:456712

Dreher, K L; Jaskot, R H; Lehmann, J R ^[1]

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1. Environmental Protection Agency, Research Triangle Park, NC (United States); and others

Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed rifa particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA. 44 refs., 5 figs., 3 tabs.

• OSTI ID: 456712
• Journal Information: Journal of Toxicology and Environmental Health, Journal Name: Journal of Toxicology and Environmental Health Journal Issue: 3 Vol. 50; ISSN 0098-4108; ISSN JTEHD6
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AIR POLLUTION
BIOLOGICAL EFFECTS
COMBUSTION
FLY ASH
FUEL OILS
LUNGS
MAN
METALS
RESPIRATORY SYSTEM DISEASES
RESPONSE MODIFYING FACTORS