Turnover of acetylcholine receptors: Mechanisms of regulation. Final report, 1 August 1985-30 November 1990
Technical Report
·
OSTI ID:449170
The synthesis, insertion and degradation of acetylcholine receptors (AChRs) of skeletal muscle cells as closely regulated both by the muscle cells and by the motor nerves that supply them. The goal of this project is to elucidate the mechanisms of regulation of the AChRs, both at the neuromuscular junctional and at extrajunctional regions. The results of our studies on junctional AChRs have shown that: Both stable and rapidly turned over (RTO) AChRs are present at normally innervated neuromuscular junctions` Synthesis and insertion of AChRs at neuromuscular junctions occurs rapidly, at a rate consistent with the rapid rate of turnover of RTOs. RTOs serve as precursors of stable AChRs. Acetylcholine receptors, RA5 Neuromuscular junctions, Motor nerves.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (United States). School of Medicine
- OSTI ID:
- 449170
- Report Number(s):
- AD-B--165975/4/XAB; CNN: Contract DAMD17-85-C-5069
- Country of Publication:
- United States
- Language:
- English
Similar Records
Rapid synthesis of acetylcholine receptors at neuromuscular junctions. (Reannouncement with new availability information)
Neural regulation of MRNA for the alpha-subunit of acetylcholine receptors: Role of neuromuscular transmission. (Reannouncement with new availability information)
Mechanism of action of lithium on acetylcholine receptor metabolism in skeletal muscle. (Reannouncement with new availability information)
Technical Report
·
Fri Dec 30 23:00:00 EST 1988
·
OSTI ID:117862
Neural regulation of MRNA for the alpha-subunit of acetylcholine receptors: Role of neuromuscular transmission. (Reannouncement with new availability information)
Technical Report
·
Sat Dec 30 23:00:00 EST 1989
·
OSTI ID:117863
Mechanism of action of lithium on acetylcholine receptor metabolism in skeletal muscle. (Reannouncement with new availability information)
Technical Report
·
Wed Dec 30 23:00:00 EST 1987
·
OSTI ID:117861