Neural regulation of MRNA for the alpha-subunit of acetylcholine receptors: Role of neuromuscular transmission. (Reannouncement with new availability information)
Technical Report
·
OSTI ID:117863
Levels of mRNA for acetylcholine receptor (AChR) subunits are relatively low in innervated skeletal muscles. Following denervation they rise rapidly, leading to increased AChR synthesis. The mechanism by which motor nerves normally regulate these mRNA levels is not yet known. In order to determine the possible role of synaptic transmission in this process, the authors have compared the effect of blockade of cholinergic ACh transmission with that of surgical denervation. Blockade of quantal ACh transmission was produced by injection of type A botulinum toxin into the soleus muscles of rats.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (United States). Dept. of Neurology
- OSTI ID:
- 117863
- Report Number(s):
- AD-A--246097/0/XAB; CNN: Contract DAMD17-85-C-5069
- Country of Publication:
- United States
- Language:
- English
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