Experimental animal studies of radon and cigarette smoke
- Pacific Northwest Lab., Richland, WA (United States)
Cigarette-smoking is a dominant cause of lung cancer and confounds risk assessment of exposure to radon decay products. Evidence in humans on the interaction between cigarette-smoking and exposure to radon decay products, although limited, indicates a possible synergy. Experimental animal data, in addition to showing synergy, also show a decrease or no change in risk with added cigarette-smoke exposures. This article reviews previous animal data developed at Compagnie Generale des Matieres Nucleaires and Pacific Northwest Laboratory (PNL) on mixed exposures to radon and cigarette smoke, and highlights new initiation-promotion-initiation (IPI) studies at PNL that were designed within the framework of a two-mutation carcinogenesis model. Also presented are the PNL exposure system, experimental protocols, dosimetry, and biological data observed to date in IPI animals.
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 44911
- Report Number(s):
- CONF-901010-Pt.2; TRN: 95:003335-0016
- Resource Relation:
- Conference: 29. Hanford symposium on health and the environment: indoor radon and lung cancer--reality or myth, Richland, WA (United States), 15-19 Oct 1990; Other Information: PBD: 1992; Related Information: Is Part Of Indoor radon and lung cancer: Reality or myth? Part 2; Cross, F.T. [ed.]; PB: 599 p.
- Country of Publication:
- United States
- Language:
- English
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