Experimental, statistical, and biological models of radon carcinogenesis
Risk models developed for underground miners have not been consistently validated in studies of populations exposed to indoor radon. Imprecision in risk estimates results principally from differences between exposures in mines as compared to domestic environments and from uncertainties about the interaction between cigarette-smoking and exposure to radon decay products. Uncertainties in extrapolating miner data to domestic exposures can be reduced by means of a broad-based health effects research program that addresses the interrelated issues of exposure, respiratory tract dose, carcinogenesis (molecular/cellular and animal studies, plus developing biological and statistical models), and the relationship of radon to smoking and other copollutant exposures. This article reviews experimental animal data on radon carcinogenesis observed primarily in rats at Pacific Northwest Laboratory. Recent experimental and mechanistic carcinogenesis models of exposures to radon, uranium ore dust, and cigarette smoke are presented with statistical analyses of animal data. 20 refs., 1 fig.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (United States)
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 5018069
- Report Number(s):
- PNL-SA-18988; CONF-9109245--1; ON: DE92002149
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Kinetics
& Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
CHRONIC EXPOSURE
CLEARANCE
COLLOIDS
DAUGHTER PRODUCTS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DUSTS
ELEMENTS
ENVIRONMENTAL EXPOSURE
EXCRETION
EXPERIMENTAL NEOPLASMS
EXTRAPOLATION
FLUIDS
GASES
INHALATION
INTAKE
ISOTOPES
LUNG CLEARANCE
MAMMALS
MATHEMATICAL MODELS
MATHEMATICS
NONMETALS
NUMERICAL SOLUTION
OCCUPATIONAL EXPOSURE
ORES
PATHOGENESIS
PROMOTERS
RADIATION DOSES
RADIATION EFFECTS
RADIOACTIVE AEROSOLS
RADIONUCLIDE KINETICS
RADON
RARE GASES
RATS
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SMOKES
SOLS
STATISTICS
SYNERGISM
TOBACCO SMOKES
TOXICITY
URANIUM ORES
VERTEBRATES