Biochemical manifestations of radiation induced damage in cultured mammalian cells

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Stud. Biophys., v. 36-37, pp. 157-163

OSTI ID:4437951

Arlett, C F; Lehmann, A R

From international conference on the bases of the biological effects of ultraviolet radiation; Brno, Czechoslovakia (2 Oct The pyrimidine dimer is believed to be the most important DNA lesion following treatment of bacteria with uv light. With mammalian cells, however, there is in general little correlation between cell survival and the ability to excise dimers from DNA. The correlation is also weak between unscheduled DNA synthesis or repair replication and cell survival. Post-replication repair or gap fllling'' is an efficient repair mechanism, which may be present in all mammalian cells. In Chinese hamster cells, two uv-sensitive lines have efficient post-replication repair capabilities, but in one of them post-replication repair is slower than in the wild type. (auth)

• Research Organization: Univ. of Sussex, Brighton, Eng.
• NSA Number: NSA-29-000540
• OSTI ID: 4437951
• Journal Information: Stud. Biophys., v. 36-37, pp. 157-163, Journal Name: Stud. Biophys., v. 36-37, pp. 157-163; ISSN STBIB
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*ANIMAL CELLS-- BIOLOGICAL RADIATION EFFECTS
*DNA-- CHEMICAL RADIATION EFFECTS
CELL CULTURES
DIMERS
HAMSTERS
N48200* --Life Sciences--Radiation Effects on Cells
PHOTON BEAMS
PYRIMIDINES
SURVIVAL TIME
ULTRAVIOLET RADIATION