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Miller-Dieker syndrome due to maternal cryptic translocation t(10;17)(q26.3;p13.3)

Journal Article · · American Journal of Medical Genetics
; ; ;  [1]
  1. Kanagawa Children`s Medical Center, Yokohama (Japan); and others

We report on a 3-month-old girl with Miller-Dieker syndrome resulting from a maternal full-cryptic translocation t(10;17)(q26.3;p13.3) detectable only by using fluorescence in situ hybridization (FISH). Parental studies using FISH are crucial for genetic counselling in cases of Miller-Dieker syndrome with submicroscopic deletion at 17p13.3. In a family with a parental cryptic translocation and high recurrence risk, prenatal diagnosis using FISH is feasible. 15 refs., 3 figs.

Sponsoring Organization:
USDOE
OSTI ID:
443761
Journal Information:
American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 59; ISSN 0148-7299; ISSN AJMGDA
Country of Publication:
United States
Language:
English

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