Omphalocele in Miller-Dieker syndrome: Expanding the phenotype

Journal Article · Mon Mar 31 04:00:00 EST 1997 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19970331)69:3<293::AID-AJMG15>3.0.CO;2-M· OSTI ID:526003

Chitayat, D ^[1]; Moola, S; Yarkoni, D ^[2]

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1. Toronto Hospital-General Division, Ontario (Canada)
2. Toronto Hospital-General Division, Ontario (Canada); and others

We report on a patient prenatally diagnosed with omphalocele, mild cerebral ventriculomegaly, nuchal fold thickening, and cystic changes in the umbilical cord who was found postnatally to have lissencephaly type I. Prenatal chromosome analysis showed a normal male karyotype; however, postnatal high resolution banding and FISH analysis, using a probe for locus D17S379 in chromosome region 17p13.3, demonstrated a deletion at 17p13.3 consistent with Miller-Dieker syndrome (MDS). A review documented four more cases with MDS/isolated lissencephaly/17p-, with omphalocele. Because MDS is a contiguous gene disorder, we speculate that a gene or genes in this region have a major role in the closure of the lateral folds or the return of the midgut from the body stalk to the abdomen at 5-11 weeks of gestation. Prenatal diagnosis of omphalocele with mild ventriculomegaly should prompt FISH analysis for a deletion in 17p13.3. 44 refs., 7 figs., 1 tab.

• OSTI ID: 526003
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 3 Vol. 69; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BANDING TECHNIQUES
BIOLOGICAL MARKERS
CHROMOSOMAL ABERRATIONS
DETECTION
DIAGNOSIS
FLUORESCENCE
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 17
IN-SITU HYBRIDIZATION
KARYOTYPE
PATIENTS
PHENOTYPE
PROBES
RESOLUTION