Quantitative measurements of endogenous and $sup 2$H-tracer variants of drugs and metabolites using a multiplexed GC/quadrupole mass spectrometer system

Conference · Mon Jan 01 04:00:00 EST 1973

OSTI ID:4427991

Jenden, D J; Cho, A K; Silverman, R W; Klein, P D; Peterson, S V ^[1]

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1. eds.

From 1st international conference on stable isotopes in chemistry, biology, and medicine; Argonne, Illinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. A description of a multiplexed quadrupole GC/MS system that was developed for quantitative isotope dilution methods of this type, and two applications that illustrate their sensitivity and versatility are presented. The first is an isotope dilution assay for amphetamine and the second is a procedure for the simultaneous measurement of endogenous and /sup 2/H-labeled tracer variants of choline and acetylcholine. (auth)

• Research Organization: Univ. of California, Los Angeles; Argonne National Lab., Ill. (USA)
• NSA Number: NSA-29-000037
• OSTI ID: 4427991
• Report Number(s): CONF-730525--
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*DEUTERIUM-- MASS SPECTROSCOPY
ACETYLCHOLINE
BENZEDRINE
CHEMICAL ANALYSIS
CHOLINE
GAS CHROMATOGRAPHY
ISOTOPE DILUTION
MASS SPECTROMETERS
N40120* --Chemistry--Analytical & Separations Chemistry-- Chemical & Spectral Procedures
N48830 --Life Sciences--New Tracer Techniques--Other
QUANTITATIVE CHEMICAL ANALYSIS
SENSITIVITY