Comparison of the effect of acridine derivatives and similar substances on the dimerization of thymine in mammalian DNA in situ and isolated

Journal Article · Mon Jan 01 00:00:00 EST 1973 · Stud. Biophys., v. 36-37, pp. 205-208

OSTI ID:4424057

Klimek, M; Shevchikova, P

From international conference on the bases of the biological effects of ultraviolet radiation; Brno, Czechoslovakia (2 Oct If the cells were exposed to the effect of varying concentrations of proflavine, acridine orange, riboflavine, and methyl green before uv irradiatlon, the most effective of these substances was proflavine, which reduced the yield of dimerization in vivo by 50%. The other substances were much less effective and accounted for a maximum 20% decrease of the dimer yield. The different results in the thymidine dimerization rate, obtained with isolated DNA and DNA in situ, are discussed. (auth)

• Research Organization: Inst. of Biophysics, Brno
• NSA Number: NSA-29-000544
• OSTI ID: 4424057
• Journal Information: Stud. Biophys., v. 36-37, pp. 205-208, Conference: International conference on the bases of the biological effects of ultraviolet radiation, Brno, Czechoslovakia, 2 Oct 1972; Other Information: Orig. Receipt Date: 30-JUN-74
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

N48200* -Life Sciences-Radiation Effects on Cells
*ACRIDINE ORANGE- RADIOSENSITIVITY EFFECTS
*ACRIDINES- RADIOSENSITIVITY EFFECTS
*ANIMAL CELLS- BIOLOGICAL RADIATION EFFECTS
*DNA- RADIOSENSITIVITY EFFECTS
*PROFLAVINE- RADIOSENSITIVITY EFFECTS
*RIBOFLAVIN- RADIOSENSITIVITY EFFECTS
*THYMINE- DIMERIZATION
PHOTON BEAMS
RESPONSE MODIFYING FACTORS
ULTRAVIOLET RADIATION