Study of the feasibility of radiation sterilization of pharmaceutical preparations of some alkaloids and sulfur containing substances (in Russian)
The feasibility of radiation sterilization was studied on ephedrine hydrochloride, atropine sulfate, scopolamine hydrobromide, strychnine nitrate, morphine hydrochloride, codeine phosphate, proserine, cysteamine hydrochloride, and unithiol in form of injectable solutions and as powders. It was shown that the sterilizing dose of radioactivity results in a breakdown of the solutions as shown by changes in the pH, color, and loss of biological activity. Alkaloid powders exhibited no changes after radiation sterilization. Deaerated solutions were also stable to the radiation but such solutions could not be prepared easily under industrial conditions. Temperature had no effect on the stability of test samples except for very low temperatures. (JPRS)
- Research Organization:
- Inst. of Nuclear Physics, Leningrad
- NSA Number:
- NSA-29-000553
- OSTI ID:
- 4424005
- Journal Information:
- Khim.-Farm. Zh., v. 7, no. 5, pp. 47-50, Journal Name: Khim.-Farm. Zh., v. 7, no. 5, pp. 47-50; ISSN KHFZA
- Country of Publication:
- USSR
- Language:
- Russian
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Related Subjects
*ATROPINE-- RADIOSTERILIZATION
*CODEINE-- RADIOSTERILIZATION
*DRUGS-- RADIOSTERILIZATION
*EPHEDRINE-- RADIOSTERILIZATION
*MEA-- RADIOSTERILIZATION
*MORPHINE-- RADIOSTERILIZATION
*STRYCHNINE-- RADIOSTERILIZATION
*UNITHIOL-- RADIOSTERILIZATION
CHEMICAL RADIATION EFFECTS
COLOR
N47322 --Isotope & Radiation Source Technology--Radiation Sources--Industrial Uses--Medical Supplies Processing
N48330* --Life Sciences--Radiation Effects on Microorganisms- -Radiosterilization of Medical Supplies
PH VALUE
STABILITY
STERILIZATION