Revertants of an Escherichia coli K-12 strain with high sensitivity to radiations and chemicals

Journal Article · Sat Sep 01 04:00:00 EDT 1973 · Mutat. Res., v. 19, no. 3, pp. 349-355

DOI:https://doi.org/10.1016/0027-5107(73)90236-4· OSTI ID:4422977

Mohn, G

The repeated isolation of mutants sensitive to radiation and also showing high spontaneous mutability indicated that in corresponding wild types some spontaneously occurring premutational lesions are repaired in a way similar to that for lesions induced chemically and by radiation. The question as to whether the high sensitivity and high mutability are pleiotropic manifestations of a single mutation or the results of different but closely linked mutations was investigated. Reveriants were treated with x radiation, ethyl methanesulfonate, isopropylmethanesulfonate, methyl methanesulfonate, N-methyl-N'-nitro- Nnitrosoquanidine, N-methyl-N-nitrosourea, and 5-methyl-DLtryptophan. Figures are presented to show survival following treatment with these agents.

• Research Organization: Zentrallaboratorium fuer Mutagenitaetspruefung der DFG, Freiburg i. B.
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-002849
• OSTI ID: 4422977
• Journal Information: Mutat. Res., v. 19, no. 3, pp. 349-355, Journal Name: Mutat. Res., v. 19, no. 3, pp. 349-355; ISSN MUREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*ESCHERICHIA COLI-- MUTATIONS
*MUTATIONS-- RADIOINDUCTION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
EMS
GENETIC EFFECTS
HETEROCYCLIC ACIDS
INDOLES
MUTAGENS
MUTANTS
NITRO COMPOUNDS
NITROSO COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOTON BEAMS
RADIOSENSITIVITY
SULFONATES
TOXICITY
X RADIATION