Quadrupole mass fragmentography in drug research
- eds.
>From first international conference on stable isotopes in chemistry, biology, and medicine; Argonne, Illinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. Quantitative mass fragmentography has made it possible to solve analytical problems in animal and human pharmacology that are important in drug research. We have developed an approach to mass fragmentography which uses a quadrupole gas chromatograph-mass spectrometer. This instrument has adequate sensitivity and precision for mass fragmentography and offers advantages over magnetic sector instruments with respect to ease of operation, wide range of ion monitoring and cost. The utility of this approach in pharmacology has been shown through studies in man and rats in which plasma levels of lidocaine and its active N-dealkylated metabolites were measured with a high degree of specificiiy. These plasma level studies helped lead to important clinical conclusions and demonstrated certain pitfalls in conventional dose-response studies of drug potency. The technique of quadrupole mass fragmentography also should have a ready application to work with stable isotopes. (auth)
- Research Organization:
- Northwestern Univ., Chicago; Argonne National Lab., Ill. (USA)
- NSA Number:
- NSA-29-000845
- OSTI ID:
- 4421328
- Report Number(s):
- CONF-730525--
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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