Effects of hydrocortisone treatment and whole-body irradiation on mouse lymphocyte stimulation in vitro

Journal Article · Thu Nov 01 00:00:00 EST 1973 · Immunology, v. 25, no. 5, pp. 753-760

OSTI ID:4413500

Ruehl, H; Vogt, W; Ruehl, U; Bochert, G; Schmidt, S

Whole-body gamma irradiation was found to reduce the number of nucleated cells in the thymus and the spleen of C57B1 mice to the same extent as hydrocortisone treatment. Equal numbers of thymus and spleen cells from either hydrocortisone-treated or irradiated e cultured and stimulated with various mitogens. An increased stimulation of DNA synthesis by PHA. Con A, and PWM was found in thymus and spleen cells after hydrocortisone treatment as well as after whole-body irradiation. In contrast, the response to LPS, known as a typical B- cell mitogen, was not affected by any of the procedures. (auth)

• Research Organization: Freie Univ., Berlin
• NSA Number: NSA-29-008018
• OSTI ID: 4413500
• Journal Information: Immunology, v. 25, no. 5, pp. 753-760, Other Information: Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: UK (United Kingdom (sent to DOE from))
• Country of Publication: United Kingdom
• Language: English

Related Subjects

N48520* -Life Sciences-Radiation Effects on Animals- Vertebrates
*LYMPHOCYTES- MITOSIS
*SPLEEN- BIOLOGICAL RADIATION EFFECTS
*THYMUS- BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
CELL NUCLEI
COMPARATIVE EVALUATIONS
DNA
GAMMA RADIATION
HYDROCORTISONE
IN VITRO
LIPOPOLYSACCHARIDES
MICE
PHOTON BEAMS
WHOLE-BODY IRRADIATION