Development of a pulsatile compartmental model of the cardiopulmonary circulation and its application to the analysis of data from quantitative radiocardiography

Conference · Sun Dec 31 23:00:00 EST 1972

OSTI ID:4412676

Castellana, F S; Drago, J A; Pierson, Jr, R N; Dagan, J; Lidofsky, L J; McClain, W J; Maskewitz, B F

From 3rd symposium on sharing of computer programs and technology in nuclear medicine; Miami, Florida, USA (16 Jun 1973). In proceedings of third symposium on sharing of computer programs and technology in nuclear medicine. Recent studies of cardiopulmonary circulation with the Anger gamma camera have demonstrated the possibility and potential of truly quantitative radiocardiography. Simultaneous measurements of the activity-time functions of an injected radioactive tracer in discrete heart-lung regions have been made available, and the proven feasibility of achieving sufficiently high count rates to measure high frequency events in the cardiac cycle demonstrated. The existing compartmental models used to analyze these data suffer from the limitation of being continuous flow approximations to a truly pulsatile system, and as a result are incapable of simulating the fine structure of the cardiac cycle. In this study, the development of a pulsatile compartmental model is detailed, and the response to a simulated right atrial injection presented. The mass balance equations are developed for a six pool representation, accounting for the pulsatile nature of the flow, and for ventricular volume variation during systole and diastole. The equations are solved by digital computer using techniques of numerical integration. The effects of an atrial septal defect and mitral insufficiency are also studied. Procedures for using the model in conjunction with experimental data for purposes of parameter estimation are suggested. (auth)

• Research Organization: Columbia Univ., New York; comps.; Oak Ridge National Lab., Tenn. (USA)
• NSA Number: NSA-29-008109
• OSTI ID: 4412676
• Report Number(s): CONF-730627--
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BLOOD CIRCULATION-- BIOLOGICAL MODELS
*HEART-- RADIOISOTOPE SCANNING
*LUNGS-- RADIOISOTOPE SCANNING
BLOOD FLOW
COMPUTER CALCULATIONS
COMPUTERS
DIAGNOSTIC TECHNIQUES
DIGITAL SYSTEMS
GAMMA CAMERAS
INJECTION
N48830* --Life Sciences--New Tracer Techniques--Other
N80600 --Mathematics & Computers
NUCLEAR MEDICINE
PATIENTS
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
TRACER TECHNIQUES