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Course of development of Leishmania enriettii infection in immunosuppressed guinea pigs

Journal Article · · Amer. J. Trop. Med. Hyg., v. 22, no. 4, pp. 477-481
OSTI ID:4406117
;
The course of development of L. enriettii infection in normal and immunosuppressed guinea pigs was studied. The leishmanial lesion in normal guinea pigs is confined and self-limiting, but in immunosuppressed animals it metastasizes and diffuses to various parts of the body, particularly the extremities. Successful immunosuppression for such studies can be achieved by administering antilymphocytic antiserum, cyclophosphamide, or whole-body irradiation. All such immunosuppressants must be continuously applied to lower the total white blood cell count to about 2,000/ml and maintain it at that level. (auth)
Research Organization:
Stanford Research Inst., Menlo Park, CA
NSA Number:
NSA-29-005345
OSTI ID:
4406117
Journal Information:
Amer. J. Trop. Med. Hyg., v. 22, no. 4, pp. 477-481, Journal Name: Amer. J. Trop. Med. Hyg., v. 22, no. 4, pp. 477-481; ISSN AJTHA
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

*GUINEA PIGS-- IMMUNOSUPPRESSION
ENDOXAN
IMMUNE SERUMS
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
PROTOZOA
TRYPANOSOMIASIS
WHOLE-BODY IRRADIATION
X RADIATION