Combined surgical and radiation injury. VI. Evaluation of wound contraction and wound histology in whole-body irradiated and bone marrow shielded rodents

Journal Article · Mon Jan 01 04:00:00 EST 1973 · J. Nucl. Biol. Med., v. 17, no. 1, pp. 30-37

OSTI ID:4405262

Donati, R M; Frank, D F

The healing of a surgically induced non-lethal skin wound was evaluated in normal rats, rats subjected to 800 R whole-body radiation, and rats subjected to 800 R radiation with bone marrow shielding. Irradiation produced a 78% thirty- day mortality that was reduced to 14% by bone marrow shielding. Wound contraction of the whole-body irradiated animals was significantly impaired when compared to the non-radiated animals. Bone marrow shielding produced a reversion of the wound contraction pattern to normal. The wounds of the whole-body irradiated animals demonstrated a less intense cellular infiltrate, increased bacterial invasion, and retarded fibrin formation with delayed healing when compared with non-irradiated wounds. Histologic evaluation revealed only subtle differences between the wounds of the nonradiated and bone marrow shielded irradiated animals. Thus, bone marrow shielding also reversed the histologic sequence of events attendant to radiation toward normal. These results suggest that the bone marrow plays an important role in wound healing in the irradiated animal. The further implications of these findings are discussed. (auth)

• Research Organization: St. Louis Univ., MO
• NSA Number: NSA-29-002925
• OSTI ID: 4405262
• Journal Information: J. Nucl. Biol. Med., v. 17, no. 1, pp. 30-37, Journal Name: J. Nucl. Biol. Med., v. 17, no. 1, pp. 30-37; ISSN JNBMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BONE MARROW-- BIOLOGICAL SHIELDING
*WOUNDS-- HEALING
BIOLOGICAL RADIATION EFFECTS
HISTOLOGY
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PARTIAL BODY IRRADIATION
PHOTON BEAMS
RATS
WHOLE- BODY IRRADIATION
X RADIATION