Induction of dominant lethality by x rays in a radiosensitive strain of yeast

Journal Article · Mon Oct 01 04:00:00 EDT 1973 · Mutat. Res., v. 20, no. 1, pp. 45-51

DOI:https://doi.org/10.1016/0027-5107(73)90096-1· OSTI ID:4404631

Ho, K S.Y.; Mortimer, R K

X-ray-survival curves of haploid, diploid, triploid, and tetraploid yeast strains homozygous for the x-ray-sensitive mutation rad52 (previously xsI) arc presented. These curves suggest that strains carrying the rad52 mutation may be more susceptible than wild type to x-ray-induced dominant lethal damage. For the crosses (+x+, rad52 x rad52, +x rad52, rad52 x+) in which only one parent was irradiated, the relationships between zygote survival and x-ray dose were similar except for rad52 x rad52. In this cross a considerably higher frequency of dominant lethal damage was observed. This observation indicates that the rad52 mutant lacks a repair system for x-ray damage and is consistent with the proposal that unrepaired chromosome damage is the event that leads to dominant lethality and reproductive cell death. (auth)

• Research Organization: Univ. of California, Berkeley
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-005301
• OSTI ID: 4404631
• Journal Information: Mutat. Res., v. 20, no. 1, pp. 45-51, Journal Name: Mutat. Res., v. 20, no. 1, pp. 45-51; ISSN MUREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*DOMINANT MUTATIONS-- RADIOINDUCTION
*LETHAL MUTATIONS-- RADIOINDUCTION
*YEASTS-- GENETIC RADIATION EFFECTS
IRRADIATION
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
PHOTON BEAMS
PLOIDY
RADIOSENSITIVITY
X RADIATION