Inhibition of neuron production by x-ray irradiation

Journal Article · Fri Sep 01 04:00:00 EDT 1972 · Kyoto Furitsu Ika Daigaku Zasshi, v. 81, no. 9, pp. 445-454

OSTI ID:4404337

Nishimura, M

Of various kinds of neurons, Purkinje cell was chosen as the target neuron for the present study. The majority of Purkinje cells in chick embryos were produced between 4 to 6 days of incubation, and that in mouse between 11 to 13 days of embryonic life. Two hundred R of x rays were administered to the chick embryos and pregnant mice at the stage of Purkinje cell production. Eight to 24 hrs after irradiation, many piknotic nuclei and nuclear debris were found in the matrix layer. Forty-eight hours later, however, the matrix layer was found to be completely recovered from the damage. Some animals, thus treated, were allowed to live until after birth and were sacrificed at the 2Oth day of age. The number of Purkinje cells in the 100 mu length at the Purkinje layer of these animals were counted to compare with that of control. The Purkinje cells in the cerebellum of irradiated mice were about 20% fewer in number for control mice. Morphological study on the Purkinje cells showed no abnormalities. (auth)

• Research Organization: Kyoto Prefectural Univ. of Medicine
• NSA Number: NSA-29-010445
• OSTI ID: 4404337
• Journal Information: Kyoto Furitsu Ika Daigaku Zasshi, v. 81, no. 9, pp. 445-454, Journal Name: Kyoto Furitsu Ika Daigaku Zasshi, v. 81, no. 9, pp. 445-454; ISSN KFIZA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*NERVE CELLS-- RADIATION INJURIES
AUTORADIOGRAPHY
CELL NUCLEI
CELL PROLIFERATION
CEREBELLUM
CHICKENS
DNA
EMBRYONIC CELLS
EMBRYOS
FETUSES
GROWTH
INCUBATION
MICE
MITOSIS
MITOTIC INDEX
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
PREGNANCY
PRENATAL IRRADIATION
THYMIDINE
TIME DEPENDENCE
TRITIUM COMPOUNDS
X RADIATION