Timing of intracranial bleeding in newborn infants

Journal Article · Thu Nov 01 04:00:00 EST 1973 · J. Nucl. Med., v. 14, no. 11, pp. 807-811

OSTI ID:4393415

Dyer, N C; Brill, A B; Tsiantos, A K; Sell, E; Victorin, L H; Stahlman, M T

Red blood cells labeled with the stable tracer 50Cr were used to investigate the timing of intracranial bleeding in immature newborn infants who required intensive nursery care. The median age at tagging the infant's red blood cells was 7.5 hr after birth. Of 69 infants from whom intraventricular clot samples were obtained at autopsy, 45 infants had the hemorrhage after tagging. In 18 infants part of the hemorrhage occurred before tagging and part afterwards. In six infants the hemorrhage occurred before tagging. For the 31 infants on whom a more precise estimate of the hemorrhage time was available, the data indicated that the intracranial bleeding occurred near the time of death. It is concluded that most of these infants' intracranial bleeding occurred after birth and after their disease process was clearly established. The use of the stable isotope 50/sup /Cr for the tagging of donor red cells was found to be a safe and practical method. The application of stable tracers, neutron activation analysis, and high-resolution gammaray spectroscopy has provided a tool for clinical investigations on high radiation risk subjects such as newborn infants without the administration of radioisotopes. (auth)

• Research Organization: Vanderbilt Univ., Nashville
• NSA Number: NSA-29-000882
• OSTI ID: 4393415
• Journal Information: J. Nucl. Med., v. 14, no. 11, pp. 807-811, Journal Name: J. Nucl. Med., v. 14, no. 11, pp. 807-811; ISSN JNMEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*HEMORRHAGE-- DIAGNOSTIC TECHNIQUES
*TRACER TECHNIQUES-- CHROMIUM 50
ACTIVATION ANALYSIS
BLOOD
BRAIN
ERYTHROCYTES
GAMMA SPECTROSCOPY
INFANTS
LABELLED COMPOUNDS
N40110 --Chemistry--Analytical & Separations Chemistry--Activation & Nuclear Reaction Procedures
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
RADIOACTIVATION
SAMPLING
STABLE ISOTOPES
TIME DEPENDENCE