Fundamentals of interaction of ionizing radiations with chemical, biochemical, and pharmaceutical systems

Journal Article · Thu Nov 01 04:00:00 EST 1973 · J. Pharm. Sci., v. 62, no. 11, pp. 1745-1757

DOI:https://doi.org/10.1002/jps.2600621102· OSTI ID:4385965

Schulman, S G

A literature review is presented of the chemical and biological effects of ionizing radiations with special reference to the pharmaceutical sciences. A review of the theoretical principles of interactions of high energy radiations with matter is presented with re gard to three stages of the process: physical, physiocochemical, and chemical. In a discussion of the irradiation of gases the ionization of gas molecules and modes of reaction of free positive ions in gas media are considered. The irradiation of liquids is discussed with regard to water, aqueous solutions, and organic liquids. The irradiation of solids is reviewed with regard to metallic crystals, valence crystals, ionic crystals, and molecular crystals. A review of chemical protection from ionizing radiations considers energy and charge transfer, scavenging intermediates, and complex formation. Effects of ionizing radiations on biological molecules are reviewed with regard to carbohydrates; amino acids and peptides; proteins and enzymes; respiratory proteins, vitamins, and coenzymes; and nucleic acids. Studies on pharmaceutical systems are concerned with radioprotective drugs such as sulfhydryl compounds, estrogens, and bacterial lipopolysaccharides. (HLW)

• Research Organization: Originating Research Org. not identified
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-007902
• OSTI ID: 4385965
• Journal Information: J. Pharm. Sci., v. 62, no. 11, pp. 1745-1757, Journal Name: J. Pharm. Sci., v. 62, no. 11, pp. 1745-1757; ISSN JPMSA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BIOLOGICAL RADIATION EFFECTS-- REVIEWS
*DRUGS-- BIOCHEMICAL REACTION KINETICS
*RADIATION CHEMISTRY-- REVIEWS
*RADIOPROTECTIVE SUBSTANCES-- REVIEWS
AMINO ACIDS
AQUEOUS SOLUTIONS
BIOLOGICAL MATERIALS
CARBOHYDRATES
COMPLEXES
CRYSTALS
ENERGY
ENZYMES
ESTROGENS
GASES
IN VITRO
IN VIVO
IONIC CRYSTALS
IONIZATION
IONIZING RADIATIONS
IONS
LIPOPOLYSACCHARIDES
LIQUIDS
MOLECULAR CRYSTALS
MOLECULES
N40300 --Chemistry--Radiation Chemistry
N48100* --Life Sciences--Radiation Effects on Biochemicals
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PEPTIDES
PROTEINS
RADIATION PROTECTION
SCAVENGING
SOLIDS
THIOLS
VITAMINS
WATER