Changes in the waking-sleeping behavior after albumin or $gamma$ globulin injection to lethally irradiated rats (in French)
Studies were performed on chronically implanted rats. These rats were subjected to whole-body irradiations of 950 rads (LD 100% 6 days). The following reproducible changes were observed: serious nonreversible disturbances in the waking-sleeping behavior, manifested principally by an almost complete disappearance of paradoxical sleep 4 days after the exposure. The intraperitioneal administration, 4 to 5 days after irradiation of one or several 250mg doses of gamma -globulin enabled the rats to recover both quantitatively and qualitatively a paradoxical sleep identical to that observed with nonirradiated animals during 2 to 3 days. On the other hand when gamma globulins are injected into nonirradiated animals, the PS level does not alter in any significant way. In addition, injections of human albumin serum carried out under the same experimental conditions, appear to modify EEG parameters, which have been disturbed by irradiation as well as producing a significant improvement in the general state of the irradiated animal, this being confirmed by the prolonged survival time observed. (FR)
- Research Organization:
- Centre de Recherches du Service de Sante des Armees, Lyon
- NSA Number:
- NSA-29-008005
- OSTI ID:
- 4384630
- Journal Information:
- Compt. Rend. Soc. Biol., v. 167, no. 1, pp. 45-50, Other Information: Orig. Receipt Date: 30-JUN-74
- Country of Publication:
- France
- Language:
- French
Similar Records
THE COURSE OF THE EXUDATIVE PHASE OF INFLAMMATION IN IRRADIATED ANIMALS
The effects of repeated low-dose sarin exposure